Number 1: On the Brink
Buy this firstAdds: New roles and events, room for a 5th player, and three optional challenges: a nastier disease, a fifth disease, and a secret Bio-Terrorist player.
Fixes: Base game stops at 4 players, and role variety wears thin. This adds both.
The one to buy first for most groups. Extra roles alone are worth it, and it lets 5 people play.
Usually a better fit for a different kind of group — still fine if it sounds fun.